| Reaction Details |
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 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
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| Ligand | BDBM50428249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_946433 (CHEMBL2339613) |
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| Kd | >20000±n/a nM |
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| Citation |  Bolshan, Y; Getlik, M; Kuznetsova, E; Wasney, GA; Hajian, T; Poda, G; Nguyen, KT; Wu, H; Dombrovski, L; Dong, A; Senisterra, G; Schapira, M; Arrowsmith, CH; Brown, PJ; Al-Awar, R; Vedadi, M; Smil, D Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett4:353-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| WD repeat-containing protein 5 |
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| Name: | WD repeat-containing protein 5 |
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| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36597.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61964 |
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| Residue: | 334 |
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| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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| BDBM50428249 |
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| n/a |
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| Name | BDBM50428249 |
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| Synonyms: | CHEMBL2337037 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClN3O3 |
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| Mol. Mass. | 359.807 |
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| SMILES | [O-][N+](=O)c1ccc(N2CCCCC2)c(NC(=O)c2ccccc2Cl)c1 |
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| Structure | 
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