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TargetFarnesyl pyrophosphate synthase
LigandBDBM50428295
Substrate/Competitorn/a
Meas. Tech.ChEMBL_947369 (CHEMBL2344602)
IC50 110±n/a nM
Citation Zhang, YZhu, WLiu, YLWang, HWang, KLi, KNo, JHAyong, LGulati, APang, RFreitas-Junior, LMorita, CTOld-Field, E Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett4:423-427 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Farnesyl pyrophosphate synthase
Name:Farnesyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:Enzyme
Mol. Mass.:48272.89
Organism:Homo sapiens (Human)
Description:P14324
Residue:419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50428295
n/a
NameBDBM50428295
Synonyms:CHEMBL2338359
TypeSmall organic molecule
Emp. Form.C12H24N2O7P2
Mol. Mass.370.2757
SMILESCCCCCCCn1cc[n+](CC(O)(P(O)(O)=O)P(O)([O-])=O)c1
Structure
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