| Reaction Details |
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 | Report a problem with these data |
| Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Ligand | BDBM50428347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_947405 (CHEMBL2345054) |
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| IC50 | 544±n/a nM |
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| Citation |  Ochoa-Puentes, C; Bauer, S; Kühnle, M; Bernhardt, G; Buschauer, A; König, B Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators. ACS Med Chem Lett4:393-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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| Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
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| Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
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| Mol. Mass.: | 72329.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UNQ0 |
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| Residue: | 655 |
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| Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
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| BDBM50428347 |
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| n/a |
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| Name | BDBM50428347 |
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| Synonyms: | CHEMBL2331716 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H59N3O11 |
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| Mol. Mass. | 866.0063 |
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| SMILES | COCCOCCOCCOc1cc2CCN(CCc3ccc(cc3)-c3ccc(C(=O)OC)c(NC(=O)c4ccc5ccccc5n4)c3)Cc2cc1OCCOCCOCCOC |
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| Structure | 
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