Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50428760 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_948440 (CHEMBL2342730) |
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IC50 | 1.9±n/a nM |
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Citation | Gillman, KW; Parker, MF; Silva, M; Degnan, AP; Tora, GO; Lodge, NJ; Li, YW; Lelas, S; Taber, M; Krause, RG; Bertekap, RL; Newton, AE; Pieschl, RL; Lengyel, KD; Johnson, KA; Taylor, SJ; Bronson, JJ; Macor, JE Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression. Bioorg Med Chem Lett23:407-11 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50428760 |
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n/a |
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Name | BDBM50428760 |
Synonyms: | BMS-817693 | CHEMBL2333637 |
Type | Small organic molecule |
Emp. Form. | C23H26F4N2O |
Mol. Mass. | 422.459 |
SMILES | CN1CCC(COCc2cc(cc(n2)C2CC2)C(F)(F)F)(CC1)c1ccc(F)cc1 |
Structure |
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