| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Ligand | BDBM50428795 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_949339 (CHEMBL2339337) |
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| IC50 | 2800±n/a nM |
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| Citation |  Scholz, T; Heyl, CL; Bernardi, D; Zimmermann, S; Kattner, L; Klein, CD Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity. Bioorg Med Chem21:795-804 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Name: | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
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| Synonyms: | EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ |
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| Type: | Protein |
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| Mol. Mass.: | 44814.62 |
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| Organism: | Escherichia coli K-12 (Enterobacteria) |
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| Description: | E. coli MurA |
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| Residue: | 419 |
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| Sequence: | MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL
GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR
PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT
IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV
AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP
AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL
SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
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| BDBM50428795 |
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| n/a |
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| Name | BDBM50428795 |
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| Synonyms: | CHEMBL2335230 | MurA inhibitor (compound 7) |
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| Type | Small organic molecule |
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| Emp. Form. | C6H3Br2NO3 |
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| Mol. Mass. | 296.901 |
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| SMILES | [O-][N+](=O)C(\Br)=C\c1ccc(Br)o1 |
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| Structure | 
|
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