Reaction Details |
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Target | Vascular endothelial growth factor receptor 2 |
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Ligand | BDBM50429484 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_943682 (CHEMBL2344826) |
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IC50 | 7730±n/a nM |
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Citation | Yang, LL; Li, GB; Ma, S; Zou, C; Zhou, S; Sun, QZ; Cheng, C; Chen, X; Wang, LJ; Feng, S; Li, LL; Yang, SY Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo. J Med Chem56:1641-55 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vascular endothelial growth factor receptor 2 |
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Name: | Vascular endothelial growth factor receptor 2 |
Synonyms: | FLK-1b | Fetal liver kinase 1b | Kinase insert domain receptor | Kinase insert domain receptor-B | Protein-tyrosine kinase receptor flk-1b | VEGFR-2 | VEGFR-2 homolog B | VGFR2_DANRE | Vascular endothelial growth factor receptor 2 homolog B | flk1b | kdr | kdrb | si:ch211-254j6.1 |
Type: | PROTEIN |
Mol. Mass.: | 153046.15 |
Organism: | Danio rerio |
Description: | ChEMBL_943682 |
Residue: | 1357 |
Sequence: | MAKTSYALLLLDILLTFNVAKAIELRFVPDPPTLNITEKTIKINASDTLQITCRGRQILE
WSTPHNRTSSETRLTISDCSGDGLFCSTLTLSKAVANETGEYRCFYKSLPKEDGKTSVAV
YVFIQDYRTPFVRIAQDYDVVFIREGEQVVIPCLVSVEDLNVTLYTKYPVKELSTDGKEV
IWDSRRGFILPSRVVSYAGVVYCQTTIRNETFQSSPYIVAVVGYKIYDLTLSPQHERLTV
GERLILNCTAHTELNVGIDFQWTFPHEKRSVNGSMSTSRYKTSSNKKKLWNSLELSNTLT
VENVTLNDTGEYICTASSGQMQKIAQASLIVYEKPFIALSDQLWQTVEAKAGDAEAKILV
KYYAYPEPAVRWYKNDQLIVLRDEYRMKFYRGVHLTIYGVTEKDAGNYTVVMTNKITKEE
QRRTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTASGGSSPVTIKWQWMPREDCPV
RFLPKSDTRMAKCDKWREMSNNTGKNPLISQTSVDERTLKTISTLKIQKAVDHALYRCIA
TNKMGQDQRVIVFQVTRFLNLSVLPSSSPIEGQDVIMRCVADRLLYYNLRWYRVANVANH
DPPPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPIPNATMMDQGLYACQVEIVGTNE
KTCLLHNLRLRALEMSRIVTNLTDQRVNVSDSTTLVCEVSGTPTPTIVWTKDNQTVMEGS
GVILKRSNRVLTIQRVKKEDSGLYICTACNQQGCESSEARISVDGAEEKMNVELIMPIGA
VVIAMFLWLLIVFVIRNRKRPNDGDLKTGYLSIILDSDDMPMDEHCERLTYDASKWEFPR
DRLKLGEPLGRGAFGQVVEATAYGIEKATTCTTVAVKMLKEGATSSEYRALMSELKILIH
IGHHLNVVNLLGACTKQGGPLMVIVEYCKHGNLSSYLKSKRGEYSPYKKRTPRMPNRREV
QQDEDPREGDLGLGTSTRLDICTGTAVCTRTGEQTYKTLQDEQESSDWDHLTMEDLISYS
FQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFGLARDVYKDPDYVRKGDARLPL
KWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVCIDESFCRRLKEGTRMRAPD
YATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQDGKDYIPLTNGEMEEELVA
PHLNVTSKRSFYAGNTEAQLHYDNAPPLGFPQQMNSSGVPVNMTGFVDIPLEHTTVMDGH
VDCGVGLSREQMKALDRQAQRPLNFSPLLRCKSKESLASESSNQTSGYQSGYHSDDAEAP
IYANEEMILKRDIRKKPPLPKRNDKFSAEVRYSAPPV
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BDBM50429484 |
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n/a |
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Name | BDBM50429484 |
Synonyms: | CHEMBL2332867 |
Type | Small organic molecule |
Emp. Form. | C21H20N6O2 |
Mol. Mass. | 388.4225 |
SMILES | CC(C)c1cccc(NC(=O)Nc2ccc(Oc3ncnc4n[nH]cc34)cc2)c1 |
Structure |
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