| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 1 |
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| Ligand | BDBM50429477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_943657 (CHEMBL2344388) |
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| IC50 | >10000±n/a nM |
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| Citation |  Yang, LL; Li, GB; Ma, S; Zou, C; Zhou, S; Sun, QZ; Cheng, C; Chen, X; Wang, LJ; Feng, S; Li, LL; Yang, SY Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo. J Med Chem56:1641-55 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 1 |
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| Name: | Serine/threonine-protein kinase PAK 1 |
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| Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
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| Type: | n/a |
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| Mol. Mass.: | 60640.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13153 |
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| Residue: | 545 |
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| Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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| BDBM50429477 |
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| n/a |
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| Name | BDBM50429477 |
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| Synonyms: | CHEMBL2332840 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12ClF3N6O2 |
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| Mol. Mass. | 448.786 |
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| SMILES | FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ncnc4n[nH]cc34)cc2)ccc1Cl |
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| Structure | 
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