| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent histone deacetylase SIR2 |
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| Ligand | BDBM29590 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_942450 (CHEMBL2345217) |
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| IC50 | 60000±n/a nM |
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| Citation |  Rambabu, D; Raja, G; Yogi Sreenivas, B; Seerapu, GP; Lalith Kumar, K; Deora, GS; Haldar, D; Rao, MV; Pal, M Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2'-quinazolines. Bioorg Med Chem Lett23:1351-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent histone deacetylase SIR2 |
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| Name: | NAD-dependent histone deacetylase SIR2 |
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| Synonyms: | MAR1 | SIR2 | SIR2_YEAST |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63277.80 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_942450 |
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| Residue: | 562 |
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| Sequence: | MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRET
NTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNP
SNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQAL
IGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSN
FFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNI
FMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKL
VQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAAS
QGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVS
EIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKN
FKCQEKDKGVYVVTSDEHPKTL
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| BDBM29590 |
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| n/a |
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| Name | BDBM29590 |
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| Synonyms: | 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one | CHEMBL86537 | splitomicin |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10O2 |
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| Mol. Mass. | 198.2173 |
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| SMILES | O=C1CCc2c(O1)ccc1ccccc21 |
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| Structure | 
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