| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50430288 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_943783 (CHEMBL2345796) |
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| IC50 | >10000±n/a nM |
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| Citation |  Tomita, N; Hayashi, Y; Suzuki, S; Oomori, Y; Aramaki, Y; Matsushita, Y; Iwatani, M; Iwata, H; Okabe, A; Awazu, Y; Isono, O; Skene, RJ; Hosfield, DJ; Miki, H; Kawamoto, T; Hori, A; Baba, A Structure-based discovery of cellular-active allosteric inhibitors of FAK. Bioorg Med Chem Lett23:1779-85 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50430288 |
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| n/a |
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| Name | BDBM50430288 |
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| Synonyms: | CHEMBL2333435 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N3O2S |
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| Mol. Mass. | 353.438 |
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| SMILES | CCc1ccc(cc1)-c1ccc2N(C)S(=O)(=O)c3cnn(C)c3-c2c1 |
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| Structure | 
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