| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-tyrosine kinase 2-beta |
|---|
| Ligand | BDBM50430287 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_943787 (CHEMBL2345800) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Tomita, N; Hayashi, Y; Suzuki, S; Oomori, Y; Aramaki, Y; Matsushita, Y; Iwatani, M; Iwata, H; Okabe, A; Awazu, Y; Isono, O; Skene, RJ; Hosfield, DJ; Miki, H; Kawamoto, T; Hori, A; Baba, A Structure-based discovery of cellular-active allosteric inhibitors of FAK. Bioorg Med Chem Lett23:1779-85 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-tyrosine kinase 2-beta |
|---|
| Name: | Protein-tyrosine kinase 2-beta |
|---|
| Synonyms: | FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 115868.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14289 |
|---|
| Residue: | 1009 |
|---|
| Sequence: | MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
|
|
|
|---|
| BDBM50430287 |
|---|
| n/a |
|---|
| Name | BDBM50430287 |
|---|
| Synonyms: | CHEMBL2333444 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H26N4O2S |
|---|
| Mol. Mass. | 410.532 |
|---|
| SMILES | CN1c2ccc(NCc3ccc(cc3)C(C)(C)C)cc2-c2c(cnn2C)S1(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
