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TargetNociceptin/mu opioid receptor
LigandBDBM50430606
Substrate/Competitorn/a
Meas. Tech.ChEMBL_947792
EC50 1.000000±n/a nM
Citation Greedy BMBradbury FThomas MPGrivas KCami-Kobeci GArchambeau ABosse KClark MJAceto MLewis JWTraynor JRHusbands SM Orvinols with mixed kappa/mu opioid receptor agonist activity. J Med Chem 56:3207-16 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nociceptin/mu opioid receptor
Name:Nociceptin/mu opioid receptor
Synonyms:MOR-1 | MUOR1 | Mu-type opioid receptor | Mu-type opioid receptor (MOR) | OPIATE Mu | Opiate non-selective | Opioid receptor B
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44503.11
Organism:Rattus norvegicus (rat)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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  Blast E-value cutoff:
BDBM50430606
n/a
NameBDBM50430606
Synonyms:CHEMBL2338714 | Isopentyl Orvinol M320
TypeSmall organic molecule
Emp. Form.C30H41NO4
Mol. Mass.479.6508
SMILESCO[C@]12C=C[C@@]3(C[C@@H]1[C@](C)(O)CCC(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 |r,wU:8.9,5.5,16.32,wD:8.10,26.38,25.25,7.8,2.1,c:3,THB:8:7:26.25:4.3,(43.61,-49.36,;42.29,-48.59,;42.3,-47.05,;40.92,-46.19,;41.8,-45.37,;40.79,-44.38,;42.31,-44.38,;43.08,-45.72,;44.62,-45.72,;44.61,-44.16,;45.96,-44.94,;45.4,-47.07,;44.61,-48.42,;45.39,-49.77,;44.61,-51.11,;46.94,-49.77,;39.97,-43.06,;38.47,-43.06,;37.73,-44.38,;36.19,-44.38,;35.41,-45.71,;36.19,-47.02,;35.39,-48.38,;37.73,-47.02,;39.17,-47.94,;40.76,-47.02,;40,-45.71,;39.22,-44.38,;39.22,-42.49,;40,-41.52,;40.78,-40.17,;42.33,-40.14,;43.68,-40.89,;43.66,-39.34,;38.47,-45.71,)|
Structure
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