| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50430877 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_945907 (CHEMBL2340521) |
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| Ki | 0.18±n/a nM |
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| Citation |  Tang, D; McKinley, ET; Hight, MR; Uddin, MI; Harp, JM; Fu, A; Nickels, ML; Buck, JR; Manning, HC Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. J Med Chem56:3429-33 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM50430877 |
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| n/a |
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| Name | BDBM50430877 |
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| Synonyms: | CHEMBL2336480 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N4O2 |
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| Mol. Mass. | 394.5099 |
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| SMILES | CCN(CC)C(=O)Cc1c(nn2c(CC)cc(CC)nc12)-c1ccc(OC)cc1 |
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| Structure | 
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