| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50430977 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_947306 (CHEMBL2343612) |
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| IC50 | 800±n/a nM |
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| Citation |  Patil, V; Sodji, QH; Kornacki, JR; Mrksich, M; Oyelere, AK 3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition. J Med Chem56:3492-506 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50430977 |
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| n/a |
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| Name | BDBM50430977 |
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| Synonyms: | CHEMBL2337869 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17NOS |
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| Mol. Mass. | 307.409 |
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| SMILES | Cc1ccc(cc1)-c1ccc(Cn2cccc(O)c2=S)cc1 |
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| Structure | 
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