Reaction Details |
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Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
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Ligand | BDBM50303763 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_947323 (CHEMBL2344107) |
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IC50 | 120000±n/a nM |
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Citation | Aik, W; Demetriades, M; Hamdan, MK; Bagg, EA; Yeoh, KK; Lejeune, C; Zhang, Z; McDonough, MA; Schofield, CJ Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem56:3680-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-ketoglutarate-dependent dioxygenase FTO |
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Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
Type: | PROTEIN |
Mol. Mass.: | 58263.75 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1515854 |
Residue: | 505 |
Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
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BDBM50303763 |
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n/a |
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Name | BDBM50303763 |
Synonyms: | (R)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acid | CHEMBL568873 |
Type | Small organic molecule |
Emp. Form. | C15H15ClN2O4 |
Mol. Mass. | 322.744 |
SMILES | CC(C)[C@@H](NC(=O)c1nc(Cl)c2ccccc2c1O)C(O)=O |r| |
Structure |
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