Reaction Details |
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Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
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Ligand | BDBM50431018 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_947323 (CHEMBL2344107) |
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IC50 | 43000±n/a nM |
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Citation | Aik, W; Demetriades, M; Hamdan, MK; Bagg, EA; Yeoh, KK; Lejeune, C; Zhang, Z; McDonough, MA; Schofield, CJ Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem56:3680-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-ketoglutarate-dependent dioxygenase FTO |
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Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
Type: | PROTEIN |
Mol. Mass.: | 58263.75 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1515854 |
Residue: | 505 |
Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
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BDBM50431018 |
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n/a |
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Name | BDBM50431018 |
Synonyms: | CHEMBL2338326 |
Type | Small organic molecule |
Emp. Form. | C18H14N2O4 |
Mol. Mass. | 322.3148 |
SMILES | OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc2ccccc2c1 |
Structure |
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