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TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial
LigandBDBM50431097
Substrate/Competitorn/a
Meas. Tech.ChEMBL_948316 (CHEMBL2340697)
IC50 4.0±n/a nM
Citation Disch, JSEvindar, GChiu, CHBlum, CADai, HJin, LSchuman, ELind, KEBelyanskaya, SLDeng, JCoppo, FAquilani, LGraybill, TLCuozzo, JWLavu, SMao, CVlasuk, GPPerni, RB Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem56:3666-79 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Name:NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:Protein
Mol. Mass.:43582.69
Organism:Homo sapiens (Human)
Description:Q9NTG7
Residue:399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
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  Blast E-value cutoff:
BDBM50431097
n/a
NameBDBM50431097
Synonyms:CHEMBL2332039
TypeSmall organic molecule
Emp. Form.C22H26N6O3S2
Mol. Mass.486.61
SMILESCCNC(=O)c1ccc(s1)C(=O)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O
Structure
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