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TargetNAD-dependent protein deacetylase sirtuin-2
LigandBDBM50431107
Substrate/Competitorn/a
Meas. Tech.ChEMBL_948317 (CHEMBL2341151)
IC50 30±n/a nM
Citation Disch, JSEvindar, GChiu, CHBlum, CADai, HJin, LSchuman, ELind, KEBelyanskaya, SLDeng, JCoppo, FAquilani, LGraybill, TLCuozzo, JWLavu, SMao, CVlasuk, GPPerni, RB Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem56:3666-79 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NAD-dependent protein deacetylase sirtuin-2
Name:NAD-dependent protein deacetylase sirtuin-2
Synonyms:NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:Hydrolase
Mol. Mass.:43172.62
Organism:Homo sapiens (Human)
Description:n/a
Residue:389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50431107
n/a
NameBDBM50431107
Synonyms:CHEMBL2332052
TypeSmall organic molecule
Emp. Form.C16H21N5OS2
Mol. Mass.363.501
SMILESCC(=S)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O
Structure
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