| Reaction Details |
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 | Report a problem with these data |
| Target | Ribonucleoside-diphosphate reductase subunit alpha |
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| Ligand | BDBM50431416 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_952415 (CHEMBL2352781) |
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| Kd | 26000±n/a nM |
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| Citation |  Nurbo, J; Ericsson, DJ; Rosenström, U; Muthas, D; Jansson, AM; Lindeberg, G; Unge, T; Karlén, A Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic--targeting Mycobacterium tuberculosis ribonucleotide reductase. Bioorg Med Chem21:1992-2000 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribonucleoside-diphosphate reductase subunit alpha |
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| Name: | Ribonucleoside-diphosphate reductase subunit alpha |
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| Synonyms: | MT3137 | RIR1_MYCTU | Ribonucleotide reductase R1 subunit | nrdE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82438.64 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_952415 |
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| Residue: | 725 |
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| Sequence: | MPPTVIAEPVASGAHASYSGGPGETDYHALNAMLNLYDADGKIQFDKDREAAHQYFLQHV
NQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKTLLDRAYAKKFRFPTFLGAFKYY
TSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTALAELLVDEIIDGRFQPATPTFLNSGK
KQRGEPVSCFLLRVEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQSS
GVIPIMKLLEDAFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLG
VVIPDITFELAKRNDDMYLFSPYDVERVYGVPFADISVTEKYYEMVDDARIRKTKIKARE
FFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSLFNEDLSYAKV
GKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGL
GQMNLHGYLARERIFYGSDEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKYA
SGEFFDKYTDQIWEPKTQKVRQLFADAGIRIPTQDDWRRLKESVQAHGIYNQNLQAVPPT
GSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLEYYEDAYEIGYEKIIDT
YAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGC
VSCML
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| BDBM50431416 |
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| n/a |
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| Name | BDBM50431416 |
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| Synonyms: | CHEMBL2348060 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H32N4O4 |
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| Mol. Mass. | 572.653 |
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| SMILES | OCCN1Cc2cccc(NC(=O)OCC3c4ccccc4-c4ccccc34)c2N[C@@H](Cc2c[nH]c3ccccc23)C1=O |r| |
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| Structure | 
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