Ki Summary

Reaction Details

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Target

Ribonucleoside-diphosphate reductase subunit alpha

Ligand

BDBM50431421

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_952415 (CHEMBL2352781)

81000±n/a nM

Citation

Nurbo, J; Ericsson, DJ; Rosenström, U; Muthas, D; Jansson, AM; Lindeberg, G; Unge, T; Karlén, A Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic--targeting Mycobacterium tuberculosis ribonucleotide reductase. Bioorg Med Chem21:1992-2000 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Ribonucleoside-diphosphate reductase subunit alpha

Name:

Ribonucleoside-diphosphate reductase subunit alpha

Synonyms:

MT3137 | RIR1_MYCTU | Ribonucleotide reductase R1 subunit | nrdE

Type:

PROTEIN

Mol. Mass.:

82438.64

Organism:

Mycobacterium tuberculosis

Description:

ChEMBL_952415

Residue:

725

Sequence:

MPPTVIAEPVASGAHASYSGGPGETDYHALNAMLNLYDADGKIQFDKDREAAHQYFLQHV
NQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKTLLDRAYAKKFRFPTFLGAFKYY
TSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTALAELLVDEIIDGRFQPATPTFLNSGK
KQRGEPVSCFLLRVEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQSS
GVIPIMKLLEDAFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLG
VVIPDITFELAKRNDDMYLFSPYDVERVYGVPFADISVTEKYYEMVDDARIRKTKIKARE
FFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSLFNEDLSYAKV
GKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGL
GQMNLHGYLARERIFYGSDEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKYA
SGEFFDKYTDQIWEPKTQKVRQLFADAGIRIPTQDDWRRLKESVQAHGIYNQNLQAVPPT
GSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLEYYEDAYEIGYEKIIDT
YAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGC
VSCML

BDBM50431421

n/a

Name

BDBM50431421

Synonyms:

CHEMBL2348055

Type

Small organic molecule

Emp. Form.

C44H48N8O14

Mol. Mass.

912.8971

SMILES

CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1cccc2CN(CC(=O)N[C@@H](Cc3ccccc3)C(O)=O)C(=O)[C@H](Cc3c[nH]c4ccccc34)Nc12 |r|

Structure