Reaction Details |
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Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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Ligand | BDBM107738 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_950925 (CHEMBL2349998) |
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Ki | 22±n/a nM |
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Citation | Dounay, AB; Anderson, M; Bechle, BM; Evrard, E; Gan, X; Kim, JY; McAllister, LA; Pandit, J; Rong, S; Salafia, MA; Tuttle, JB; Zawadzke, LE; Verhoest, PR PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Bioorg Med Chem Lett23:1961-6 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
Synonyms: | 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II |
Type: | Enzyme |
Mol. Mass.: | 47353.09 |
Organism: | Homo sapiens (Human) |
Description: | Q8N5Z0 |
Residue: | 425 |
Sequence: | MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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BDBM107738 |
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n/a |
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Name | BDBM107738 |
Synonyms: | CHEMBL2347113 | US8933095, 22 |
Type | Small organic molecule |
Emp. Form. | C15H18N4O3 |
Mol. Mass. | 302.3284 |
SMILES | COc1cccc(Cc2nn(C)c3N(O)C(=O)[C@@H](N)Cc23)c1 |r| |
Structure |
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