| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Ligand | BDBM50432208 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_950925 (CHEMBL2349998) |
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| Ki | 1.6±n/a nM |
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| Citation |  Dounay, AB; Anderson, M; Bechle, BM; Evrard, E; Gan, X; Kim, JY; McAllister, LA; Pandit, J; Rong, S; Salafia, MA; Tuttle, JB; Zawadzke, LE; Verhoest, PR PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. Bioorg Med Chem Lett23:1961-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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| Synonyms: | 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II |
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| Type: | Enzyme |
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| Mol. Mass.: | 47353.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N5Z0 |
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| Residue: | 425 |
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| Sequence: | MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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| BDBM50432208 |
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| n/a |
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| Name | BDBM50432208 |
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| Synonyms: | CHEMBL2347110 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N2O3 |
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| Mol. Mass. | 298.3364 |
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| SMILES | COc1cc2N(O)C(=O)[C@@H](N)Cc2cc1Cc1ccccc1 |r| |
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| Structure | 
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