| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
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| Ligand | BDBM50432305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_951594 (CHEMBL2351269) |
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| IC50 | 250±n/a nM |
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| Citation |  Leung, CY; Langille, AM; Mancuso, J; Tsantrizos, YS Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate. Bioorg Med Chem21:2229-40 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Farnesyl pyrophosphate synthase |
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| Name: | Farnesyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48272.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14324 |
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| Residue: | 419 |
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| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| BDBM50432305 |
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| n/a |
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| Name | BDBM50432305 |
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| Synonyms: | CHEMBL2347863 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N3O6P2S |
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| Mol. Mass. | 451.33 |
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| SMILES | OP(O)(=O)C(Nc1ncnc2sc(cc12)-c1ccc2ccccc2c1)P(O)(O)=O |
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| Structure | 
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