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TargetC-X-C chemokine receptor type 2
LigandBDBM50432432
Substrate/Competitorn/a
Meas. Tech.ChEMBL_953473 (CHEMBL2351084)
Ki 1980±n/a nM
Citation Karlström, SNordvall, GSohn, DHettman, ATurek, DÅhlin, KKers, AClaesson, MSlivo, CLo-Alfredsson, YPetersson, CBessidskaia, GSvensson, PHRein, TJerning, EMalmberg, ÅAhlgen, CRay, CVares, LIvanov, VJohansson, R Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1). J Med Chem56:3177-90 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 2
Name:C-X-C chemokine receptor type 2
Synonyms:C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:Protein
Mol. Mass.:40767.88
Organism:Homo sapiens (Human)
Description:P25025
Residue:360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50432432
n/a
NameBDBM50432432
Synonyms:CHEMBL2349329
TypeSmall organic molecule
Emp. Form.C19H22N6OS2
Mol. Mass.414.548
SMILESCC(C)C[C@H](CO)Nc1nc(SCc2cccc(c2)C#N)nc2nc(N)sc12 |r|
Structure
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