| Reaction Details |
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 | Report a problem with these data |
| Target | CX3C chemokine receptor 1 |
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| Ligand | BDBM50432456 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_953474 (CHEMBL2351085) |
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| Ki | 43±n/a nM |
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| Citation |  Karlström, S; Nordvall, G; Sohn, D; Hettman, A; Turek, D; Åhlin, K; Kers, A; Claesson, M; Slivo, C; Lo-Alfredsson, Y; Petersson, C; Bessidskaia, G; Svensson, PH; Rein, T; Jerning, E; Malmberg, Å; Ahlgen, C; Ray, C; Vares, L; Ivanov, V; Johansson, R Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1). J Med Chem56:3177-90 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| CX3C chemokine receptor 1 |
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| Name: | CX3C chemokine receptor 1 |
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| Synonyms: | C-X3-C chemokine receptor 1 | CMKBRL1 | CX3C1_HUMAN | CX3CR1 | GPR13 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40399.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_953474 |
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| Residue: | 355 |
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| Sequence: | MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSK
KPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNAMCKFTTAFFFIGFFGSIFFI
TVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKENECLGDYP
EVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVF
FLFWTPYNVMIFLETLKLYDFFPSCDMRKDLRLALSVTETVAFSHCCLNPLIYAFAGEKF
RRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL
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| BDBM50432456 |
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| n/a |
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| Name | BDBM50432456 |
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| Synonyms: | CHEMBL2349302 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22ClN5O2S2 |
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| Mol. Mass. | 451.993 |
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| SMILES | COC(=O)[C@@H](CC(C)C)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12 |r| |
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| Structure | 
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