Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A
LigandBDBM50432736
Substrate/Competitorn/a
Meas. Tech.ChEMBL_952909 (CHEMBL2351898)
Ki 870±n/a nM
Citation Wang, YKirschner, AFabian, AKGopalakrishnan, RKress, CHoogeland, BKoch, UKozany, CBracher, AHausch, F Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. J Med Chem56:3922-35 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP1A
Name:Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:Isomerase
Mol. Mass.:11953.09
Organism:Homo sapiens (Human)
Description:P62942
Residue:108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50432736
n/a
NameBDBM50432736
Synonyms:CHEMBL2348607
TypeSmall organic molecule
Emp. Form.C24H26Cl2N2O5S
Mol. Mass.525.445
SMILESCOc1cc2CCN3C(=O)[C@@H]4CCCC(N4S(=O)(=O)c4cc(Cl)cc(Cl)c4)[C@@]3(C)c2c(OC)c1 |r,TLB:16:15:13.12.11:27.7.8|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: