Reaction Details | |||
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Target | Serine/threonine-protein kinase mTOR | ||
Ligand | BDBM50433046 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_955789 (CHEMBL2379606) | ||
Ki | 7.8±n/a nM | ||
Citation | Cheng, H; Hoffman, JE; Le, PT; Pairish, M; Kania, R; Farrell, W; Bagrodia, S; Yuan, J; Sun, S; Zhang, E; Xiang, C; Dalvie, D; Rahavendran, SV Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series. Bioorg Med Chem Lett23:2787-92 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase mTOR | |||
Name: | Serine/threonine-protein kinase mTOR | ||
Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
Type: | Rapamycin target protein | ||
Mol. Mass.: | 288917.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P42345 | ||
Residue: | 2549 | ||
Sequence: |
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BDBM50433046 | |||
n/a | |||
Name | BDBM50433046 | ||
Synonyms: | CHEMBL2375965 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H25N5O3 | ||
Mol. Mass. | 431.487 | ||
SMILES | Cc1nc(N)nc2n([C@H]3CC[C@@H](CC3)OCO)c(=O)c(cc12)-c1cnc2ccccc2c1 |r,wU:11.14,wD:8.7,(65.77,-15.8,;65.77,-17.34,;64.44,-18.11,;64.44,-19.65,;63.11,-20.42,;65.77,-20.42,;67.1,-19.65,;68.44,-20.43,;68.43,-21.96,;67.09,-22.73,;67.09,-24.26,;68.41,-25.04,;69.75,-24.28,;69.76,-22.73,;68.4,-26.58,;67.07,-27.34,;65.74,-26.56,;69.79,-19.66,;71.12,-20.43,;69.79,-18.1,;68.45,-17.32,;67.11,-18.1,;71.13,-17.34,;72.46,-18.12,;73.8,-17.36,;73.79,-15.82,;75.12,-15.05,;75.13,-13.51,;73.79,-12.74,;72.46,-13.51,;72.46,-15.04,;71.13,-15.81,)| | ||
Structure |