Reaction Details | |||
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Target | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | ||
Ligand | BDBM50433047 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_955790 (CHEMBL2379607) | ||
Ki | 10±n/a nM | ||
Citation | Cheng, H; Hoffman, JE; Le, PT; Pairish, M; Kania, R; Farrell, W; Bagrodia, S; Yuan, J; Sun, S; Zhang, E; Xiang, C; Dalvie, D; Rahavendran, SV Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series. Bioorg Med Chem Lett23:2787-92 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | |||
Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | ||
Synonyms: | PI3-kinase p110 subunit alpha | PI3-kinase p110-alpha subunit | PI3K | PK3CA_MOUSE | Phosphatidylinositol 3-kinase p110α (p110α) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3K alpha) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Pik3ca | PtdIns-3-kinase p110 | ||
Type: | Protein | ||
Mol. Mass.: | 124421.84 | ||
Organism: | Mus musculus (Mouse) | ||
Description: | P42337 | ||
Residue: | 1068 | ||
Sequence: |
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BDBM50433047 | |||
n/a | |||
Name | BDBM50433047 | ||
Synonyms: | CHEMBL2375966 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H24N6O3 | ||
Mol. Mass. | 384.4323 | ||
SMILES | Cc1nc(N)nc2n([C@H]3CC[C@@H](CC3)OCO)c(=O)c(cc12)-c1cnn(C)c1 |r,wU:11.14,wD:8.7,(54.37,-15.83,;54.38,-17.37,;53.05,-18.15,;53.05,-19.69,;51.71,-20.46,;54.38,-20.46,;55.71,-19.69,;57.05,-20.47,;57.04,-22.01,;55.7,-22.77,;55.69,-24.3,;57.02,-25.08,;58.36,-24.32,;58.37,-22.78,;57.01,-26.62,;55.67,-27.39,;54.34,-26.61,;58.4,-19.7,;59.73,-20.47,;58.4,-18.14,;57.05,-17.36,;55.71,-18.14,;59.74,-17.38,;61.13,-18.03,;62.17,-16.89,;61.41,-15.55,;62.05,-14.15,;59.9,-15.86,)| | ||
Structure |