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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | ||
| Ligand | BDBM50433052 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_955790 (CHEMBL2379607) | ||
| Ki | 26±n/a nM | ||
| Citation |  Cheng, H; Hoffman, JE; Le, PT; Pairish, M; Kania, R; Farrell, W; Bagrodia, S; Yuan, J; Sun, S; Zhang, E; Xiang, C; Dalvie, D; Rahavendran, SV Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series. Bioorg Med Chem Lett23:2787-92 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | |||
| Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | ||
| Synonyms: | PI3-kinase p110 subunit alpha | PI3-kinase p110-alpha subunit | PI3K | PK3CA_MOUSE | Phosphatidylinositol 3-kinase p110α (p110α) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3K alpha) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Pik3ca | PtdIns-3-kinase p110 | ||
| Type: | Protein | ||
| Mol. Mass.: | 124421.84 | ||
| Organism: | Mus musculus (Mouse) | ||
| Description: | P42337 | ||
| Residue: | 1068 | ||
| Sequence: |
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| BDBM50433052 | |||
| n/a | |||
| Name | BDBM50433052 | ||
| Synonyms: | CHEMBL2375970 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24N6O3 | ||
| Mol. Mass. | 384.4323 | ||
| SMILES | Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCO)c(=O)c(cc12)-c1cnn(C)c1 |r,wD:8.7,11.14,(66.3,-1.69,;66.31,-3.23,;64.98,-4,;64.98,-5.54,;63.64,-6.31,;66.31,-6.31,;67.64,-5.55,;68.98,-6.32,;68.97,-7.86,;70.3,-8.63,;70.29,-10.17,;68.95,-10.94,;67.62,-10.16,;67.63,-8.62,;68.94,-12.48,;67.6,-13.24,;66.27,-12.46,;70.33,-5.55,;71.66,-6.32,;70.33,-3.99,;68.98,-3.21,;67.64,-3.99,;71.67,-3.24,;73.06,-3.88,;74.1,-2.74,;73.34,-1.4,;73.98,-0,;71.83,-1.71,)| | ||
| Structure | 
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