| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Ligand | BDBM50433274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_957854 (CHEMBL2378967) |
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| IC50 | 126±n/a nM |
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| Citation |  Barlind, JG; Buckett, LK; Crosby, SG; Davidsson, Ö; Emtenäs, H; Ertan, A; Jurva, U; Lemurell, M; Gutierrez, PM; Nilsson, K; O'Mahony, G; Petersson, AU; Redzic, A; Wågberg, F; Yuan, ZQ Identification and design of a novel series of MGAT2 inhibitors. Bioorg Med Chem Lett23:2721-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Name: | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
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| Synonyms: | GGNT3 | GNT-III | GlcNAc-T III | MGAT3 | MGAT3_HUMAN | N-acetylglucosaminyltransferase III | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61324.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107586 |
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| Residue: | 533 |
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| Sequence: | MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQA
SPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKP
GTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGP
SCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCES
NFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDG
VSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLE
VVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCS
WCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEH
MYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV
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| BDBM50433274 |
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| n/a |
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| Name | BDBM50433274 |
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| Synonyms: | CHEMBL2376321 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19F2N3O5S |
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| Mol. Mass. | 439.433 |
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| SMILES | CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(OC(F)F)cc1 |r| |
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| Structure | 
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