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TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
LigandBDBM50433269
Substrate/Competitorn/a
Meas. Tech.ChEMBL_957856
IC50 5.0±n/a nM
Citation Barlind JGBuckett LKCrosby SGDavidsson Emtenäs HErtan AJurva ULemurell MGutierrez PMNilsson KO'Mahony GPetersson AURedzic AWågberg FYuan ZQ Identification and design of a novel series of MGAT2 inhibitors. Bioorg Med Chem Lett 23:2721-6 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Name:Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:Beta-1,2-N-acetylglucosaminyltransferase II | GNT-II | GlcNAc-T II | Mannoside acetylglucosaminyltransferase 2 | Mgat2 | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Type:PROTEIN
Mol. Mass.:51045.37
Organism:Mus musculus
Description:ChEMBL_107583
Residue:442
Sequence:
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKSDALGPPLLDAEPVRGAGHLAVSVGIR
RVSNESAAPLVPAVPRPEVDNLTLRYRSLVYQLNFDQMLRNVGNDGTWSPGELVLVVQVH
NRPEYLRLLIDSLRKAQGIQEVLVIFSHDFWSAEINSLISRVDFCPVLQVFFPFSIQLYP
NEFPGSDPRDCPRDLKKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERV
KVLQDYTGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPGCDVLSLGTYTTIRSFYGIAD
KVDVKTWKSTEHNMGLALTRDAYQKLIECTDTFCTYDDYNWDWTLQYLTLACLPKIWKVL
VPQAPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNSNKQYLFPETLVIGEKFPMAAISPP
RKNGGWGDIRDHELCKSYRRLQ
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  Blast E-value cutoff:
BDBM50433269
n/a
NameBDBM50433269
Synonyms:CHEMBL2376303
TypeSmall organic molecule
Emp. Form.C18H17F2N3O4S
Mol. Mass.409.407
SMILESCC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F |r|
Structure
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