| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50433356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_955840 (CHEMBL2379697) |
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| Ki | 85±n/a nM |
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| Citation |  Andaloussi, M; Lim, HD; van der Meer, T; Sijm, M; Poulie, CB; de Esch, IJ; Leurs, R; Smits, RA A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787. Bioorg Med Chem Lett23:2663-70 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | HH4R | HRH4_MOUSE | Hrh4 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44272.75 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay. |
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| Residue: | 391 |
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| Sequence: | MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAIS
DFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAV
SYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTIT
MLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSN
PGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRG
RKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLY
PLCHRRFQKAFWKILCVTKQPALSQNQSVSS
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| BDBM50433356 |
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| n/a |
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| Name | BDBM50433356 |
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| Synonyms: | CHEMBL2376801 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H20N6 |
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| Mol. Mass. | 272.3488 |
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| SMILES | CCc1cnc2c(nc(N)nc2c1)N1CC[C@H](C1)NC |r| |
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| Structure | 
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