| Reaction Details |
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 | Report a problem with these data |
| Target | Cycloartenol synthase |
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| Ligand | BDBM50433365 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_956102 (CHEMBL2379127) |
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| IC50 | >20000±n/a nM |
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| Citation |  Lange, S; Keller, M; Müller, C; Oliaro-Bosso, S; Balliano, G; Bracher, F Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors. Eur J Med Chem63:758-64 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cycloartenol synthase |
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| Name: | Cycloartenol synthase |
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| Synonyms: | CAS1 | CAS1_ARATH | CYC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86025.20 |
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| Organism: | Arabidopsis thaliana |
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| Description: | ChEMBL_956102 |
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| Residue: | 759 |
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| Sequence: | MWKLKIAEGGSPWLRTTNNHVGRQFWEFDPNLGTPEDLAAVEEARKSFSDNRFVQKHSAD
LLMRLQFSRENLISPVLPQVKIEDTDDVTEEMVETTLKRGLDFYSTIQAHDGHWPGDYGG
PMFLLPGLIITLSITGALNTVLSEQHKQEMRRYLYNHQNEDGGWGLHIEGPSTMFGSVLN
YVTLRLLGEGPNDGDGDMEKGRDWILNHGGATNITSWGKMWLSVLGAFEWSGNNPLPPEI
WLLPYFLPIHPGRMWCHCRMVYLPMSYLYGKRFVGPITSTVLSLRKELFTVPYHEVNWNE
ARNLCAKEDLYYPHPLVQDILWASLHKIVEPVLMRWPGANLREKAIRTAIEHIHYEDENT
RYICIGPVNKVLNMLCCWVEDPNSEAFKLHLPRIHDFLWLAEDGMKMQGYNGSQLWDTGF
AIQAILATNLVEEYGPVLEKAHSFVKNSQVLEDCPGDLNYWYRHISKGAWPFSTADHGWP
ISDCTAEGLKAALLLSKVPKAIVGEPIDAKRLYEAVNVIISLQNADGGLATYELTRSYPW
LELINPAETFGDIVIDYPYVECTSAAIQALISFRKLYPGHRKKEVDECIEKAVKFIESIQ
AADGSWYGSWAVCFTYGTWFGVKGLVAVGKTLKNSPHVAKACEFLLSKQQPSGGWGESYL
SCQDKVYSNLDGNRSHVVNTAWAMLALIGAGQAEVDRKPLHRAARYLINAQMENGDFPQQ
EIMGVFNRNCMITYAAYRNIFPIWALGEYRCQVLLQQGE
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| BDBM50433365 |
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| n/a |
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| Name | BDBM50433365 |
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| Synonyms: | CHEMBL2377450 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H41N |
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| Mol. Mass. | 319.5676 |
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| SMILES | CNCCCC1=C2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CCC1 |r,c:5| |
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| Structure | 
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