| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 |
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| Ligand | BDBM50433369 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_956654 (CHEMBL2380181) |
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| IC50 | 38±n/a nM |
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| Citation |  Schonbrunn, E; Betzi, S; Alam, R; Martin, MP; Becker, A; Han, H; Francis, R; Chakrasali, R; Jakkaraj, S; Kazi, A; Sebti, SM; Cubitt, CL; Gebhard, AW; Hazlehurst, LA; Tash, JS; Georg, GI Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem56:3768-82 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 |
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| Name: | Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 |
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| Synonyms: | CDK3/Cyclin E | CDK3/E |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 3 |
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| Synonyms: | CDK3 | CDK3/Cyclin E | CDK3_HUMAN | CDKN3 | Cyclin-dependent kinase 3 | Cyclin-dependent kinase 3 (CDK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 35053.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00526 |
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| Residue: | 305 |
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| Sequence: | MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH
PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS
HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY
TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSF
PKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVL
QRFRH
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| Component 2 |
| Name: | G1/S-specific cyclin-E1 |
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| Synonyms: | CCNE | CCNE1 | CCNE1_HUMAN |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 47073.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 410 |
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| Sequence: | MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
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| BDBM50433369 |
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| n/a |
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| Name | BDBM50433369 |
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| Synonyms: | CHEMBL2377825 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N5O5S2 |
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| Mol. Mass. | 419.435 |
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| SMILES | Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)sc1C(=O)c1ccccc1[N+]([O-])=O |
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| Structure | 
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