| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-A2/Cyclin-dependent kinase 1 |
|---|
| Ligand | BDBM50433369 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_956657 (CHEMBL2380184) |
|---|
| IC50 | 7.6±n/a nM |
|---|
| Citation |  Schonbrunn, E; Betzi, S; Alam, R; Martin, MP; Becker, A; Han, H; Francis, R; Chakrasali, R; Jakkaraj, S; Kazi, A; Sebti, SM; Cubitt, CL; Gebhard, AW; Hazlehurst, LA; Tash, JS; Georg, GI Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem56:3768-82 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-A2/Cyclin-dependent kinase 1 |
|---|
| Name: | Cyclin-A2/Cyclin-dependent kinase 1 |
|---|
| Synonyms: | CDK1/Cyclin A | Cyclin-Dependent Kinase 1 (CDK1) |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | CDK1 was expressed in a baculovirus expression system and was partially purified. Cyclin A was purified separately and mixed with CDK1 before assays. |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 1 |
|---|
| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 34101.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06493 |
|---|
| Residue: | 297 |
|---|
| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
|
|
|
|---|
| Component 2 |
| Name: | Cyclin-A2 |
|---|
| Synonyms: | CCN1 | CCNA | CCNA1 | CCNA2 | CCNA2_HUMAN | Cyclin A | Cyclin-A |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 48550.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P20248 |
|---|
| Residue: | 432 |
|---|
| Sequence: | MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRG
LAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKI
EREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHE
DIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYID
RFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLK
VLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAF
HLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHG
VSLLNPPETLNL
|
|
|
|---|
| BDBM50433369 |
|---|
| n/a |
|---|
| Name | BDBM50433369 |
|---|
| Synonyms: | CHEMBL2377825 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H13N5O5S2 |
|---|
| Mol. Mass. | 419.435 |
|---|
| SMILES | Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)sc1C(=O)c1ccccc1[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
