Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMethionine aminopeptidase 2
LigandBDBM47468
Substrate/Competitorn/a
Meas. Tech.ChEMBL_957169 (CHEMBL2378707)
EC50>100000±n/a nM
Citation Zhang, F; Bhat, S; Gabelli, SB; Chen, X; Miller, MS; Nacev, BA; Cheng, YL; Meyers, DJ; Tenney, K; Shim, JS; Crews, P; Amzel, LM; Ma, D; Liu, JO Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem56:3996-4016 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine aminopeptidase 2
Name:Methionine aminopeptidase 2
Synonyms:Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:Enzyme
Mol. Mass.:52884.45
Organism:Homo sapiens (Human)
Description:P50579
Residue:478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM47468
n/a
NameBDBM47468
Synonyms:MLS000769840 | N-(2-phenylethyl)-2-(2-pyridinyl)-4-quinazolinamine | N-(2-phenylethyl)-2-pyridin-2-yl-quinazolin-4-amine | N-(2-phenylethyl)-2-pyridin-2-ylquinazolin-4-amine | Phenethyl-(2-pyridin-2-yl-quinazolin-4-yl)-amine | SMR000434573 | cid_937982 | phenethyl-[2-(2-pyridyl)quinazolin-4-yl]amine
TypeSmall organic molecule
Emp. Form.C21H18N4
Mol. Mass.326.3944
SMILESC(Cc1ccccc1)Nc1nc(nc2ccccc12)-c1ccccn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: