| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM50433473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_959272 (CHEMBL2383839) |
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| IC50 | 23±n/a nM |
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| Citation |  Greco, MN; Connelly, MA; Leo, GC; Olson, MW; Powell, E; Huang, Z; Hawkins, M; Smith, C; Schalk-Hihi, C; Darrow, AL; Xin, H; Lang, W; Damiano, BP; Hlasta, DJ A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice. Bioorg Med Chem Lett23:2595-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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| BDBM50433473 |
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| n/a |
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| Name | BDBM50433473 |
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| Synonyms: | CHEMBL2381070 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F2N3O3S |
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| Mol. Mass. | 433.472 |
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| SMILES | Fc1cc(F)cc(OCCCCCNC(=O)SCc2nnc(o2)-c2ccccc2)c1 |
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| Structure | 
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