| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM50433474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_959457 (CHEMBL2384495) |
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| IC50 | >33000±n/a nM |
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| Citation |  Greco, MN; Connelly, MA; Leo, GC; Olson, MW; Powell, E; Huang, Z; Hawkins, M; Smith, C; Schalk-Hihi, C; Darrow, AL; Xin, H; Lang, W; Damiano, BP; Hlasta, DJ A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice. Bioorg Med Chem Lett23:2595-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg |
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| Type: | Protein |
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| Mol. Mass.: | 56643.58 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q9WVG5 |
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| Residue: | 500 |
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| Sequence: | MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPE
QEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHID
IYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
SRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNN
SGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVA
HSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWF
HKCQDGWKMKNKTSPFVNLA
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| BDBM50433474 |
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| n/a |
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| Name | BDBM50433474 |
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| Synonyms: | CHEMBL2381068 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24FNO2 |
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| Mol. Mass. | 329.4085 |
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| SMILES | Fc1ccccc1COC(=O)NCCCCCCc1ccccc1 |
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| Structure | 
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