| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
|---|
| Ligand | BDBM50433476 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_959519 (CHEMBL2384686) |
|---|
| IC50 | 1100±n/a nM |
|---|
| Citation |  Huang, X; Cheng, CC; Fischmann, TO; Duca, JS; Richards, M; Tadikonda, PK; Reddy, PA; Zhao, L; Siddiqui, MA; Parry, D; Davis, N; Seghezzi, W; Wiswell, D; Shipps, GW Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. Bioorg Med Chem Lett23:2590-4 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interleukin-1 receptor-associated kinase 4 |
|---|
| Name: | Interleukin-1 receptor-associated kinase 4 |
|---|
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51519.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NWZ3 |
|---|
| Residue: | 460 |
|---|
| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
|
|
|
|---|
| BDBM50433476 |
|---|
| n/a |
|---|
| Name | BDBM50433476 |
|---|
| Synonyms: | CHEMBL2381116 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22N6O3S |
|---|
| Mol. Mass. | 450.513 |
|---|
| SMILES | COc1ccc2CN(C(=O)c2c1)c1nc(cs1)C(=O)Nc1cnccc1N1CCNCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
