Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50433489 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_959662 (CHEMBL2382855) |
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EC50 | 250±n/a nM |
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Citation | Huang, X; Cheng, CC; Fischmann, TO; Duca, JS; Richards, M; Tadikonda, PK; Reddy, PA; Zhao, L; Siddiqui, MA; Parry, D; Davis, N; Seghezzi, W; Wiswell, D; Shipps, GW Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. Bioorg Med Chem Lett23:2590-4 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50433489 |
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n/a |
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Name | BDBM50433489 |
Synonyms: | CHEMBL2381248 |
Type | Small organic molecule |
Emp. Form. | C23H23N5O3S |
Mol. Mass. | 449.525 |
SMILES | COc1ccc2CN(C(=O)c2c1)c1nc(cs1)C(=O)Nc1ccccc1N1CCNCC1 |
Structure |
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