| Reaction Details |
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 | Report a problem with these data |
| Target | LIM domain kinase 1 |
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| Ligand | BDBM50433630 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_959026 (CHEMBL2382839) |
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| IC50 | 18±n/a nM |
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| Citation |  Karra, S; Xiao, Y; Chen, X; Liu-Bujalski, L; Huck, B; Sutton, A; Goutopoulos, A; Askew, B; Josephson, K; Jiang, X; Shutes, A; Shankar, V; Noonan, T; Garcia-Berrios, G; Dong, R; Dhanabal, M; Tian, H; Wang, Z; Clark, A; Goodstal, S SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett23:3081-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| LIM domain kinase 1 |
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| Name: | LIM domain kinase 1 |
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| Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 72591.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_4505001 |
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| Residue: | 647 |
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| Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
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| BDBM50433630 |
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| n/a |
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| Name | BDBM50433630 |
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| Synonyms: | CHEMBL2380834 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H16F4N4O2 |
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| Mol. Mass. | 492.4245 |
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| SMILES | Fc1ccc(C(=O)Nc2ccc(Nc3ccnc4[nH]c(=O)c5ccccc5c34)cc2)c(c1)C(F)(F)F |
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| Structure | 
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