| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-activating factor acetylhydrolase |
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| Ligand | BDBM50433665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_959030 (CHEMBL2382963) |
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| IC50 | 0.230000±n/a nM |
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| Citation |  Wang, K; Xu, W; Zhang, W; Mo, M; Wang, Y; Shen, J Triazole derivatives: a series of Darapladib analogues as orally active Lp-PLA2 inhibitors. Bioorg Med Chem Lett23:2897-901 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-activating factor acetylhydrolase |
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| Name: | Platelet-activating factor acetylhydrolase |
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| Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50084.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_156212 |
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| Residue: | 441 |
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| Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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| BDBM50433665 |
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| n/a |
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| Name | BDBM50433665 |
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| Synonyms: | CHEMBL2380967 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H41F4N7OS |
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| Mol. Mass. | 731.848 |
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| SMILES | CN(CCN1CCCC1)Cc1nnc(Cn2c3CCCc3c(=O)nc2SCc2ccc(F)cc2)n1Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F |
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| Structure | 
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