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TargetMAP kinase-activated protein kinase 2
LigandBDBM50433764
Substrate/Competitorn/a
Meas. Tech.ChEMBL_959963 (CHEMBL2383905)
IC50 4000±n/a nM
Citation Meng, ZCiavarri, JPMcRiner, AZhao, YZhao, LReddy, PAZhang, XFischmann, TOWhitehurst, CArshad Siddiqui, M Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors. Bioorg Med Chem Lett23:2863-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
MAP kinase-activated protein kinase 2
Name:MAP kinase-activated protein kinase 2
Synonyms:MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:Serine/threonine-protein kinase
Mol. Mass.:45579.87
Organism:Homo sapiens (Human)
Description:P49137
Residue:400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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  Blast E-value cutoff:
BDBM50433764
n/a
NameBDBM50433764
Synonyms:CHEMBL2381607
TypeSmall organic molecule
Emp. Form.C19H21ClN6O
Mol. Mass.384.863
SMILESN[C@H]1CC[C@@H](CC1)Nc1ncc(C(N)=O)c2nc(cn12)-c1ccc(Cl)cc1 |r,wU:4.7,wD:1.0,(27.43,-20.12,;26.1,-19.35,;26.1,-17.81,;24.76,-17.03,;23.44,-17.81,;23.43,-19.35,;24.76,-20.12,;22.11,-17.04,;22.1,-15.5,;20.77,-14.73,;20.77,-13.19,;22.1,-12.42,;22.1,-10.88,;23.43,-10.1,;20.76,-10.11,;23.44,-13.18,;24.9,-12.7,;25.81,-13.94,;24.91,-15.19,;23.44,-14.72,;27.35,-13.93,;28.13,-15.26,;29.67,-15.25,;30.43,-13.91,;31.97,-13.9,;29.64,-12.58,;28.11,-12.59,)|
Structure
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