Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase Chk1

Ligand

BDBM50433764

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_959964 (CHEMBL2383906)

IC50

50000±n/a nM

Citation

Meng, Z; Ciavarri, JP; McRiner, A; Zhao, Y; Zhao, L; Reddy, PA; Zhang, X; Fischmann, TO; Whitehurst, C; Arshad Siddiqui, M Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors. Bioorg Med Chem Lett23:2863-7 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase Chk1

Name:

Serine/threonine-protein kinase Chk1

Synonyms:

CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

54443.02

Organism:

Homo sapiens (Human)

Description:

gi_166295192

Residue:

476

Sequence:

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT

BDBM50433764

n/a

Name

BDBM50433764

Synonyms:

CHEMBL2381607

Type

Small organic molecule

Emp. Form.

C19H21ClN6O

Mol. Mass.

384.863

SMILES

N[C@H]1CC[C@@H](CC1)Nc1ncc(C(N)=O)c2nc(cn12)-c1ccc(Cl)cc1 |r,wU:4.7,wD:1.0,(27.43,-20.12,;26.1,-19.35,;26.1,-17.81,;24.76,-17.03,;23.44,-17.81,;23.43,-19.35,;24.76,-20.12,;22.11,-17.04,;22.1,-15.5,;20.77,-14.73,;20.77,-13.19,;22.1,-12.42,;22.1,-10.88,;23.43,-10.1,;20.76,-10.11,;23.44,-13.18,;24.9,-12.7,;25.81,-13.94,;24.91,-15.19,;23.44,-14.72,;27.35,-13.93,;28.13,-15.26,;29.67,-15.25,;30.43,-13.91,;31.97,-13.9,;29.64,-12.58,;28.11,-12.59,)|

Structure