Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Serine/threonine-protein kinase Chk1 | ||
Ligand | BDBM50433769 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_959964 (CHEMBL2383906) | ||
IC50 | 890±n/a nM | ||
Citation | Meng, Z; Ciavarri, JP; McRiner, A; Zhao, Y; Zhao, L; Reddy, PA; Zhang, X; Fischmann, TO; Whitehurst, C; Arshad Siddiqui, M Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors. Bioorg Med Chem Lett23:2863-7 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase Chk1 | |||
Name: | Serine/threonine-protein kinase Chk1 | ||
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 54443.02 | ||
Organism: | Homo sapiens (Human) | ||
Description: | gi_166295192 | ||
Residue: | 476 | ||
Sequence: |
| ||
BDBM50433769 | |||
n/a | |||
Name | BDBM50433769 | ||
Synonyms: | CHEMBL2381600 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H23ClN6O | ||
Mol. Mass. | 398.889 | ||
SMILES | CN[C@H]1CC[C@@H](CC1)Nc1ncc(C(N)=O)n2cc(nc12)-c1ccc(Cl)cc1 |r,wU:5.8,wD:2.1,(67.27,-1.42,;67.27,-2.96,;68.6,-3.73,;68.6,-5.27,;69.94,-6.05,;71.27,-5.27,;71.26,-3.73,;69.94,-2.96,;72.61,-6.04,;72.61,-7.58,;71.28,-8.35,;71.28,-9.89,;72.62,-10.66,;72.62,-12.2,;71.29,-12.97,;73.95,-12.97,;73.96,-9.89,;75.43,-10.35,;76.32,-9.1,;75.41,-7.86,;73.95,-8.34,;77.86,-9.09,;78.64,-10.42,;80.17,-10.41,;80.94,-9.07,;82.48,-9.06,;80.15,-7.74,;78.62,-7.76,)| | ||
Structure |