| Reaction Details |
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 | Report a problem with these data |
| Target | Malate dehydrogenase, cytoplasmic |
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| Ligand | BDBM23229 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_959386 (CHEMBL2384177) |
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| IC50 | 6780±n/a nM |
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| Citation |  Dragovich, PS; Fauber, BP; Corson, LB; Ding, CZ; Eigenbrot, C; Ge, H; Giannetti, AM; Hunsaker, T; Labadie, S; Liu, Y; Malek, S; Pan, B; Peterson, D; Pitts, K; Purkey, HE; Sideris, S; Ultsch, M; VanderPorten, E; Wei, B; Xu, Q; Yen, I; Yue, Q; Zhang, H; Zhang, X Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett23:3186-94 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Malate dehydrogenase, cytoplasmic |
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| Name: | Malate dehydrogenase, cytoplasmic |
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| Synonyms: | Cytosolic malate dehydrogenase | MDH1 | MDHA | MDHC_HUMAN | Malate dehydrogenase cytoplasmic | Malate dehydrogenase, cytoplasmic |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36427.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456624 |
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| Residue: | 334 |
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| Sequence: | MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
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| BDBM23229 |
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| n/a |
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| Name | BDBM23229 |
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| Synonyms: | Oxamic acid derivative, 7 | [(4-{2-[(5-hydroxy-2-{[(4-methoxyphenyl)methyl]carbamoyl}-4-oxo-4H-chromen-7-yl)oxy]ethyl}-2-methoxyphenyl)carbamoyl]formic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26N2O10 |
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| Mol. Mass. | 562.5241 |
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| SMILES | COc1ccc(CNC(=O)c2cc(=O)c3c(O)cc(OCCc4ccc(NC(=O)C(O)=O)c(OC)c4)cc3o2)cc1 |
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| Structure | 
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