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TargetMalate dehydrogenase cytoplasmic
LigandBDBM50433836
Substrate/Competitorn/a
Meas. Tech.ChEMBL_959386
IC50>10000±n/a nM
Citation Dragovich PSFauber BPCorson LBDing CZEigenbrot CGe HGiannetti AMHunsaker TLabadie SLiu YMalek SPan BPeterson DPitts KPurkey HESideris SUltsch MVanderPorten EWei BXu QYen IYue QZhang HZhang X Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett 23:3186-94 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Malate dehydrogenase cytoplasmic
Name:Malate dehydrogenase cytoplasmic
Synonyms:Cytosolic malate dehydrogenase | Malate dehydrogenase, cytoplasmic
Type:PROTEIN
Mol. Mass.:36427.72
Organism:Homo sapiens (Human)
Description:ChEMBL_1456624
Residue:334
Sequence:
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50433836
n/a
NameBDBM50433836
Synonyms:CHEMBL2382337
TypeSmall organic molecule
Emp. Form.C19H14ClN5O4S2
Mol. Mass.475.929
SMILESNS(=O)(=O)c1ccc(NC(=O)CSc2nc(-c3ccc(Cl)cc3)c(C#N)c(=O)[nH]2)cc1
Structure
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