| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50434126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_958898 (CHEMBL2384806) |
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| IC50 | 23000±n/a nM |
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| Citation |  Olson, DE; Wagner, FF; Kaya, T; Gale, JP; Aidoud, N; Davoine, EL; Lazzaro, F; Weïwer, M; Zhang, YL; Holson, EB Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem56:4816-20 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50434126 |
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| n/a |
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| Name | BDBM50434126 |
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| Synonyms: | CHEMBL2381517 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O3 |
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| Mol. Mass. | 284.3098 |
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| SMILES | ONC(=O)c1cccc(c1)C(=O)NCCc1ccccc1 |
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| Structure | 
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