Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMacrophage metalloelastase
LigandBDBM50434223
Substrate/Competitorn/a
Meas. Tech.ChEMBL_960929 (CHEMBL2388547)
Ki 7.0±n/a nM
Citation Mori, MMassaro, ACalderone, VFragai, MLuchinat, CMordini, A Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold. ACS Med Chem Lett4:565-9 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:Enzyme
Mol. Mass.:54012.99
Organism:Homo sapiens (Human)
Description:P39900
Residue:470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50434223
n/a
NameBDBM50434223
Synonyms:CHEMBL2385486
TypeSmall organic molecule
Emp. Form.C16H17NO4S
Mol. Mass.319.375
SMILESOC(=O)CNS(=O)(=O)CCc1ccc(cc1)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: