| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine receptor H3 |
|---|
| Ligand | BDBM50434393 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_961066 (CHEMBL2389497) |
|---|
| Ki | 11±n/a nM |
|---|
| Citation |  Gao, Z; Hurst, WJ; Guillot, E; Czechtizky, W; Lukasczyk, U; Nagorny, R; Pruniaux, MP; Schwink, L; Sanchez, JA; Stengelin, S; Tang, L; Winkler, I; Hendrix, JA; George, PG Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I). Bioorg Med Chem Lett23:3416-20 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine receptor H3 |
|---|
| Name: | Histamine receptor H3 |
|---|
| Synonyms: | n/a |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48611.84 |
|---|
| Organism: | Macaca mulatta (Rhesus macaque) |
|---|
| Description: | Q865E1 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
|
|
|
|---|
| BDBM50434393 |
|---|
| n/a |
|---|
| Name | BDBM50434393 |
|---|
| Synonyms: | CHEMBL2387284 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H35N5O |
|---|
| Mol. Mass. | 433.589 |
|---|
| SMILES | CC1CCCN1C1CCN(C1)c1ccc(NC(=O)N2CCN(CC2)c2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
