Reaction Details |
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Target | Histamine receptor H3 |
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Ligand | BDBM50434393 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_961066 (CHEMBL2389497) |
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Ki | 11±n/a nM |
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Citation | Gao, Z; Hurst, WJ; Guillot, E; Czechtizky, W; Lukasczyk, U; Nagorny, R; Pruniaux, MP; Schwink, L; Sanchez, JA; Stengelin, S; Tang, L; Winkler, I; Hendrix, JA; George, PG Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I). Bioorg Med Chem Lett23:3416-20 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine receptor H3 |
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Name: | Histamine receptor H3 |
Synonyms: | n/a |
Type: | Enzyme |
Mol. Mass.: | 48611.84 |
Organism: | Macaca mulatta (Rhesus macaque) |
Description: | Q865E1 |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
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BDBM50434393 |
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n/a |
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Name | BDBM50434393 |
Synonyms: | CHEMBL2387284 |
Type | Small organic molecule |
Emp. Form. | C26H35N5O |
Mol. Mass. | 433.589 |
SMILES | CC1CCCN1C1CCN(C1)c1ccc(NC(=O)N2CCN(CC2)c2ccccc2)cc1 |
Structure |
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