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TargetMAP kinase-activated protein kinase 2
LigandBDBM50434505
Substrate/Competitorn/a
Meas. Tech.ChEMBL_961826 (CHEMBL2389966)
IC50 79±n/a nM
Citation Xiao, DPalani, AHuang, XSofolarides, MZhou, WChen, XAslanian, RGuo, ZFossetta, JTian, FTrivedi, PSpacciapoli, PWhitehurst, CELundell, D Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors. Bioorg Med Chem Lett23:3262-6 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
MAP kinase-activated protein kinase 2
Name:MAP kinase-activated protein kinase 2
Synonyms:MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:Serine/threonine-protein kinase
Mol. Mass.:45579.87
Organism:Homo sapiens (Human)
Description:P49137
Residue:400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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  Blast E-value cutoff:
BDBM50434505
n/a
NameBDBM50434505
Synonyms:CHEMBL2385531
TypeSmall organic molecule
Emp. Form.C23H22ClN3O2
Mol. Mass.407.893
SMILESCN1c2ccc(cc2Cc2cc(oc2C1=O)-c1ccc(Cl)cc1)N1CCNCC1
Structure
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